What is our Advanced Opioid Management® solution?

A clinically-driven solution combatting a nationally recognized crisis, our Advanced Opioid Management suite of services provide a dynamic way to fight opioid abuse, meeting patients at the doctor’s office, at the pharmacy and at home. Watch our video to learn more about the opioid crisis and how together, we can make a change.

Watch the video to learn about the opioid crisis and how together, we can make a difference.

How does the Advanced Opioid Management solution work?

At the doctor's office:

  • Alerts sent when opioids are prescribed to patients with mental health prescriptions or prenatal vitamin prescription
  • Alerts sent when patient activity indicates potential abuse
  • Prescriber education & peer comparison
  • Alerts sent recommending proactive naloxone therapy when appropriate
  • Enhanced Fraud, Waste & Abuse

At home:

  • Proactive Neuroscience Therapeutic Research Center pharmacist outreach will include Medication Assisted Therapy support
  • Mental health, suicide and additional hotline information delivered to patients
  • Informational letter detailing the risks of opioid use
  • Supply of drug disposal bags, when needed, reducing the chance for excessive use or distribution

At the pharmacy:

  • Seven-day supply limit for adults initiating opioid therapy for each of their first 4 fills5
  • Three-day supply limit for children initiating opioid therapy for each of their first 4 fills6
  • Prior authorization required for members starting opioids who accumulate > 90 MME
  • Prior authorization required for members who accumulate > 200MME
  • Prior authorization on first fill of a long-acting opioid to encourage a safe start
  • Safer fentanyl utilization initiatives
  • Opioid adjacent therapy quantity limits

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Automated message at point of care via EHR on potential misuse and abuse, along with morphine equivalent dose (MED) communication

Enhanced prior authorization stops long-acting opioid prescription without a previous long-acting opioid in member's claim history

Auto-lock management triggers an intervention that directs patients to a single provider

Educational letter after first fill outlines the potential risks associated with opioid use

Proactive outreach from specialized Neuroscience Therapeutic Resource CenterSM pharmacists triggered when potential abuse or misuse is identified

Deactivation drug disposal bags provide patients with a safe way to dispose of unused opioids - thereby preventing future opioid misuse

Auto-lock management keeps members locked into one pharmacy

Pharmacy interventions for members accumulating greater than 200mg MED

Concurrent drug utilization review programs help ensure that opioid prescriptions are appropriate, medically necessary and unlikely to result in adverse medical consequences

First-time users prescribed short-acting opioids are restricted to an initial 7-day supply

On average, the program has seen a nearly 55% reduction
in the average days' supply for new opioid-prescribed patients.7
(from 18.6 days' supply per prescription to 8.3)

The first 90 days of the program has seen a nearly


in the average days' supply for new opioid-prescribed patients — from 18.6 days' supply per prescription to 7.5

Prevention is key

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2 Million

people are addicted to prescription narcotics4

The fight starts here

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Our Lasting Legacy of Education

Express Scripts has a long history of working to make the use of prescription medications safer, and our Advanced Opioid Management solution is just one of the products of our efforts.

We support national and state intervention. However, we know that government regulations and initiatives are only one part of the solution. The answers lie in education, coordination and action. Our efforts are receiving national attention, and you can join us in creating change. Preview our leadership library below, and start learning about how you can directly contribute to solving the opioid crisis.

The odds of continuing opioid use after one year are


after receiving a ten-day supply1

The opioid crisis accounts for

$25 billion

in lost productivity annually3